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<<< Press Releases
The Winners of the Amedeo Prize 2008
Press Release 2008/07/07 - For immediate release - The voters of the Amedeo Medical Literature Service have awarded the 2008 Amedeo Prize
to the Wellcome Trust Case Control Consortium for its
article Genome-wide association study of 14,000 cases of seven common diseases
and 3,000 shared controls, published in Nature on June 6th, 2007 (447:661-78; The second winner is Jennifer L. Baker, from the Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark. Her article Childhood body-mass index and the risk of coronary heart disease in adulthood was published in the New England Journal of Medicine on December 6th, 2007 (357:2329-37; full-text article).The third winner is Kazutoshi Takahashi, from the Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan. His article Induction of pluripotent stem cells from adult human fibroblasts by defined factors was published in Cell on November 30th, 2007 (131:861-72; full-text article).According to the rules of the Amedeo Prize, the prize money of 22,000 Euro will be divided as follows: 12,532 Euro for the winner of the Amedeo Prize 2008, 4,808 Euro for Dr. Baker, and 4,660 Euro for Dr. Takahashi.The Medical Article of the Year 2008 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78 - Full-text article To determine the genetics behind some frequent medical conditions, the Wellcome Trust Case Control Consortium analyzed 2,000 samples from each of seven diseases (type 1 diabetes, type 2 diabetes, coronary heart disease, hypertension, bipolar disorder, rheumatoid arthritis and Crohn's disease). For each disease, the case populations were compared to 3,000 controls. The study brought together 50 leading research groups and 200 scientists in the field of human genetics from dozens of UK institutions. Over two years, they analyzed almost 10 billion pieces of genetic information. The study increased the number of genes known to play a role in the development of some of the most common diseases. Many of these genes that were found are in areas of the genome not previously thought to have been related to the diseases. For more information, please check http://www.wtccc.org.uk/info/070606.shtml.
Wellcome Trust Case Control Consortium The primary purpose of the Wellcome Trust Case Control Consortium (WTCCC) is to accelerate efforts to identify genome sequence variants influencing major causes of human morbidity and mortality, through implementation and analysis of large-scale genome-wide association studies. For more information, please check http://www.wtccc.org.uk.
2nd Winner: Jennifer Baker Childhood body-mass index and the risk of coronary heart disease in adulthood. New England Journal of Medicine 2007; 357:2329-37; full-text article). Childhood obesity is rising at an alarming rate worldwide. Although there are concurrent negative health consequences, the long-term health consequences are not well understood. Therefore, using data on 276.835 Danish schoolchildren, we investigated if childhood body size, assessed by body mass index (BMI; weight in kilograms/height in meters squared), from 7 to 13 years of age was associated with coronary heart disease in adulthood. We found that as childhood BMI increased at each age from 7 to 13 years and for both boys and girls, the risk of heart disease in adulthood increased. The results showed that even a few extra kilograms in weight significantly increased the risk of heart disease. Our findings suggest that as more children are becoming heavier worldwide, greater numbers will be at risk of coronary heart disease in adulthood. Institute of Preventive Medicine, Center for Health and Society Located in the historic buildings of the former Copenhagen Community Hospital, the Institute of Preventive Medicine is part of the vibrant University of Copenhagen campus. Founded in 1962, its research mission initally focused on the determinants of psychiatric conditions. Since that time, it has expanded to include other topics of public health importance such as obesity, heart disease, cancer and general mortality. With a staff of more than 30 full-time researchers, several associated researchers and numerous international collaborators, the Institute is a dynamic epidemiolgical research environment. For more information, please check http://www.ipm.regionh.dkAmedeo Prize The Amedeo Prize is for the first authors of the three most popular medical articles published
during the previous year and listed in PubMed (see the The 2008 winners were selected by more than 1600 subscribers to the Amedeo Medical Literature Service in a four-step process that lasted 7 months:
Amedeo is now in its 11th year. At the beginning of 2008, Amedeo covers 100 topics for more than 100,000 subscriptions and is among the most popular medical websites. It is a free service due to unrestricted educational grants from numerous pharmaceutical companies. The men behind Amedeo are Bernd Sebastian Kamps, his brother Stephan Kamps, and several dozen physicians (see "The Amedeo Story").
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