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The Wellcome Trust Case Control Consortium (WTCCC)

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.

Medical Article of the Year 2008

Free full-text


Management Committee
Paul R. Burton1, David G. Clayton2, Lon R. Cardon3, Nick Craddock4, Panos Deloukas5, Audrey Duncanson6, Dominic P. Kwiatkowski3,5, Mark I. McCarthy3,7, Willem H. Ouwehand8,9, Nilesh J. Samani10, John A. Todd2 & Peter Donnelly, (Chair)11

Data and Analysis Committee
Jeffrey C. Barrett3, Paul R. Burton1, Dan Davison11, Peter Donnelly11, Doug Easton12, David Evans3, Hin-Tak Leung2, Jonathan L. Marchini11, Andrew P. Morris3, Chris C. A. Spencer11, Martin D. Tobin1, Lon R. Cardon, (Co-Chair)3 & David G. Clayton, (Co-Chair)2

UK Blood Services and University of Cambridge Controls
Antony P. Attwood5,8, James P. Boorman8,9, Barbara Cant8, Ursula Everson13, Judith M. Hussey14, Jennifer D. Jolley8, Alexandra S. Knight8, Kerstin Koch8, Elizabeth Meech15, Sarah Nutland2, Christopher V. Prowse16, Helen E. Stevens2, Niall C. Taylor8, Graham R. Walters17, Neil M. Walker2, Nicholas A. Watkins8,9, Thilo Winzer8, John A. Todd2 & Willem H. Ouwehand8,9

1958 Birth Cohort Controls
Richard W. Jones18, Wendy L. McArdle18, Susan M. Ring18, David P. Strachan19 & Marcus Pembrey18,20

Bipolar Disorder
Gerome Breen21, David St Clair, (Aberdeen)21, Sian Caesar22, Katherine Gordon-Smith22,23, Lisa Jones, (Birmingham)22, Christine Fraser23, Elaine K. Green23, Detelina Grozeva23, Marian L. Hamshere23, Peter A. Holmans23, Ian R. Jones23, George Kirov23, Valentina Moskvina23, Ivan Nikolov23, Michael C. O'Donovan23, Michael J. Owen23, Nick Craddock, (Cardiff)23, David A. Collier24, Amanda Elkin24, Anne Farmer24, Richard Williamson24, Peter McGuffin, (London)24, Allan H. Young25 & I. Nicol Ferrier, (Newcastle)25

Coronary Artery Disease
Stephen G. Ball26, Anthony J. Balmforth26, Jennifer H. Barrett26, D. Timothy Bishop26, Mark M. Iles26, Azhar Maqbool26, Nadira Yuldasheva26, Alistair S. Hall, (Leeds)26, Peter S. Braund10, Paul R. Burton1, Richard J. Dixon10, Massimo Mangino10, Suzanne Stevens10, Martin D. Tobin1, John R. Thompson1 & Nilesh J. Samani, (Leicester)10

Crohn's Disease
Francesca Bredin27, Mark Tremelling27, Miles Parkes, (Cambridge)27, Hazel Drummond28, Charles W. Lees28, Elaine R. Nimmo28, Jack Satsangi, (Edinburgh)28, Sheila A. Fisher29, Alastair Forbes30, Cathryn M. Lewis29, Clive M. Onnie29, Natalie J. Prescott29, Jeremy Sanderson31, Christopher G. Mathew, (London)29, Jamie Barbour32, M. Khalid Mohiuddin32, Catherine E. Todhunter, (Newcastle)32, John C. Mansfield32, Tariq Ahmad33, Fraser R. Cummings33 & Derek P. Jewell, (Oxford)33

Hypertension
John Webster, (Aberdeen)34, Morris J. Brown35, David G. Clayton, (Cambridge)2, G. Mark Lathrop, (Evry)36, John Connell37, Anna Dominiczak, (Glasgow)37, Nilesh J. Samani, (Leicester)10, Carolina A. Braga Marcano38, Beverley Burke38, Richard Dobson38, Johannie Gungadoo38, Kate L. Lee38, Patricia B. Munroe38, Stephen J. Newhouse38, Abiodun Onipinla38, Chris Wallace38, Mingzhan Xue38, Mark Caulfield, (London)38 & Martin Farrall, (Oxford)39

Rheumatoid Arthritis
Anne Barton40, The Biologics in RA Genetics and Genomics (BRAGGS)55, Ian N. Bruce40, Hannah Donovan40, Steve Eyre40, Paul D. Gilbert40, Samantha L. Hider40, Anne M. Hinks40, Sally L. John40, Catherine Potter40, Alan J. Silman40, Deborah P. M. Symmons40, Wendy Thomson40 & Jane Worthington40

Type 1 Diabetes
David G. Clayton2, David B. Dunger2,41, Sarah Nutland2, Helen E. Stevens2, Neil M. Walker2, Barry Widmer2,41 & John A. Todd2

Type 2 Diabetes
Timothy M. Frayling42,43, Rachel M. Freathy42,43, Hana Lango42,43, John R. B. Perry42,43, Beverley M. Shields43, Michael N. Weedon42,43, Andrew T. Hattersley, (Exeter)42,43, Graham A. Hitman, (London)44, Mark Walker, (Newcastle)45, Kate S. Elliott3,7, Christopher J. Groves7, Cecilia M. Lindgren3,7, Nigel W. Rayner3,7, Nicholas J. Timpson3,46, Eleftheria Zeggini3,7 & Mark I. McCarthy, (Oxford)3,7

Tuberculosis
Melanie Newport47, Giorgio Sirugo, (Gambia)47, Emily Lyons3, Fredrik Vannberg3 & Adrian V. S. Hill, (Oxford)3

Ankylosing Spondylitis
Linda A. Bradbury48, Claire Farrar49, Jennifer J. Pointon48, Paul Wordsworth49 & Matthew A. Brown48,49

Autoimmune Thyroid Disease
Jayne A. Franklyn50, Joanne M. Heward50, Matthew J. Simmonds50 & Stephen C. L. Gough50

Breast Cancer
Sheila Seal51, Breast Cancer Susceptibility Collaboration (UK)55, Michael R. Stratton51,52 & Nazneen Rahman51

Multiple Sclerosis
Maria Ban53, An Goris53, Stephen J. Sawcer53 & Alastair Compston53

Gambian Controls
David Conway47, Muminatou Jallow47, Melanie Newport47, Giorgio Sirugo, (Gambia)47, Kirk A. Rockett3 & Dominic P. Kwiatkowski, (Oxford)3,5

DNA, Genotyping, Data QC and Informatics
Suzannah J. Bumpstead5, Amy Chaney5, Kate Downes2,5, Mohammed J. R. Ghori5, Rhian Gwilliam5, Sarah E. Hunt5, Michael Inouye5, Andrew Keniry5, Emma King5, Ralph McGinnis5, Simon Potter5, Rathi Ravindrarajah5, Pamela Whittaker5, Claire Widden5, David Withers5, Panos Deloukas, (Wellcome Trust Sanger Institute Hinxton)6, Hin-Tak Leung2, Sarah Nutland2, Helen E. Stevens2, Neil M. Walker2 & John A. Todd, (Cambridge)2

Statistics
Doug Easton12, David G. Clayton, (Cambridge)2, Paul R. Burton1, Martin D. Tobin, (Leicester)1, Jeffrey C. Barrett3, David Evans3, Andrew P. Morris3, Lon R. Cardon, (Oxford)3, Niall J. Cardin11, Dan Davison11, Teresa Ferreira11, Joanne Pereira-Gale11, Ingileif B. Hallgrimsdóttir11, Bryan N. Howie11, Jonathan L. Marchini11, Chris C. A. Spencer11, Zhan Su11, Yik Ying Teo3,11, Damjan Vukcevic11 & Peter Donnelly, (Oxford)11

Primary Investigators
David Bentley5,54, Matthew A. Brown48,49, Lon R. Cardon3, Mark Caulfield38, David G. Clayton2, Alistair Compston53, Nick Craddock23, Panos Deloukas5, Peter Donnelly11, Martin Farrall39, Stephen C. L. Gough50, Alistair S. Hall26, Andrew T. Hattersley42,43, Adrian V. S. Hill3, Dominic P. Kwiatkowski3,5, Christopher G. Mathew29, Mark I. McCarthy3,7, Willem H. Ouwehand8,9, Miles Parkes27, Marcus Pembrey18,20, Nazneen Rahman51, Nilesh J. Samani10, Michael R. Stratton51,52, John A. Todd2 & Jane Worthington40




  1. Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.
  2. Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
  3. Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  4. Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
  5. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  6. The Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.
  7. Oxford Centre for Diabetes, Endocrinology and Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
  8. Department of Haematology, University of Cambridge, Long Road, Cambridge CB2 2PT, UK.
  9. National Health Service Blood and Transplant, Cambridge Centre, Long Road, Cambridge CB2 2PT, UK.
  10. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
  11. Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
  12. Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
  13. National Health Service Blood and Transplant, Sheffield Centre, Longley Lane, Sheffield S5 7JN, UK.
  14. National Health Service Blood and Transplant, Brentwood Centre, Crescent Drive, Brentwood CM15 8DP, UK.
  15. The Welsh Blood Service, Ely Valley Road, Talbot Green, Pontyclun CF72 9WB, UK.
  16. The Scottish National Blood Transfusion Service, Ellen's Glen Road, Edinburgh EH17 7QT, UK.
  17. National Health Service Blood and Transplant, Southampton Centre, Coxford Road, Southampton SO16 5AF, UK.
  18. Avon Longitudinal Study of Parents and Children, University of Bristol, 24 Tyndall Avenue, Bristol BS8 1TQ, UK.
  19. Division of Community Health Services, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
  20. Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
  21. University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.
  22. Department of Psychiatry, Division of Neuroscience, Birmingham University, Birmingham B15 2QZ, UK.
  23. Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
  24. SGDP, The Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
  25. School of Neurology, Neurobiology and Psychiatry, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.
  26. LIGHT and LIMM Research Institutes, Faculty of Medicine and Health, University of Leeds, Leeds LS1 3EX, UK.
  27. IBD Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK.
  28. Gastrointestinal Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
  29. Department of Medical & Molecular Genetics, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, UK.
  30. Institute for Digestive Diseases, University College London Hospitals Trust, London, NW1 2BU, UK.
  31. Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
  32. Department of Gastroenterology & Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  33. Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK.
  34. Medicine and Therapeutics, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Grampian AB9 2ZB, UK.
  35. Clinical Pharmacology Unit and the Diabetes and Inflammation Laboratory, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK.
  36. Centre National de Genotypage, 2, Rue Gaston Cremieux, Evry, Paris 91057, France.
  37. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.
  38. Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine, Charterhouse Square, London EC1M 6BQ, UK.
  39. Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  40. arc Epidemiology Research Unit, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT, UK.
  41. Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
  42. Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK.
  43. Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5DU, UK.
  44. Centre for Diabetes and Metabolic Medicine, Barts and The London, Royal London Hospital, Whitechapel, London E1 1BB, UK.
  45. Diabetes Research Group, School of Clinical Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  46. The MRC Centre for Causal Analyses in Translational Epidemiology, Bristol University, Canynge Hall, Whiteladies Rd, Bristol BS2 8PR, UK.
  47. MRC Laboratories, Fajara, The Gambia.
  48. Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Qld 4102, Australia.
  49. Botnar Research Centre, University of Oxford, Headington, Oxford OX3 7BN, UK.
  50. Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  51. Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK.
  52. Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  53. Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
  54. †Present address: Illumina Cambridge, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.



 

 
 
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